Tetanus and diphtheria toxoids vaccine

Generic Name: tetanus and diphtheria toxoids vaccine (Td, adult) (TET a nus and dif THEER ee a TOX oids)

Brand names: Decavac (Td), Tetanus-Diphtheria Toxoids, Adult (Td), Tetanus-Diphtheria Toxoids, Adult (Td), Tenivac (Td)

What is tetanus and diphtheria toxoids vaccine?

Tetanus and diphtheria are serious diseases caused by bacteria.

Tetanus (lockjaw) causes painful tightening of the muscles, usually all over the body. It can lead to "locking" of the jaw so the victim cannot open the mouth or swallow. Tetanus leads to death in about 1 out of 10 cases.

Diphtheria causes a thick coating in the nose, throat, and airways. It can lead to breathing problems, paralysis, heart failure, or death.

Diphtheria is spread from person to person. Tetanus enters the body through a cut or wound.

The tetanus and diphtheria toxoids vaccine (also called Td) is used to help prevent these diseases in adults and children who are at least 7 years old.

This vaccine works by exposing you to a small dose of the bacteria or a protein from the bacteria, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body.

Like any vaccine, the tetanus and diphtheria toxoids vaccine may not provide protection from disease in every person.

What is the most important information I should know about this vaccine?

The tetanus and diphtheria toxoids vaccine is given in a series of shots. The first shot is usually given to a person who is at least 7 years old. The booster shots are then given 4 to 8 weeks after the first shot, and 6 to 12 months after the second shot. After the initial series, a booster dose is given every 10 years.

A booster shot is also recommended in children who are 11 or 12 years old if more than 5 years have passed since the child's last tetanus and diphtheria vaccine.

If it has been longer than 5 years since your last booster, you may need an emergency booster shot if you have been exposed to tetanus through a skin wound.

Your individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by the health department of the state you live in.

The adult version of this vaccine (Td) should not be given to anyone under the age of 7 years old. Another vaccine is available for use in younger children and infants.

Be sure you receive all recommended doses of this vaccine. If you do not receive the full series of vaccines, you may not be fully protected against the disease.

You can still receive a vaccine if you have a cold or fever. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.

You should not receive a booster vaccine if you have had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with tetanus or diphtheria is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

What should I discuss with my healthcare provider before receiving this vaccine?

You should not receive this vaccine if you have ever had a life-threatening allergic reaction to any vaccine containing diphtheria or tetanus, or if you have:

• 
  

  severe or uncontrolled epilepsy or other seizure disorder; or

  
  


• 
  

  if you have received cancer chemotherapy or radiation treatment in the past 3 months.

  
  

You may not be able to receive this vaccine if you have ever received a similar vaccine that caused any of the following:

• 
  

  a very high fever (over 104 degrees);

  
  


• 
  

  a neurologic disorder or disease affecting the brain;

  
  


• 
  

  fainting or going into shock;

  
  


• 
  

  Guillain-Barré syndrome (within 6 weeks after receiving a diphtheria, tetanus, or pertussis vaccine);

  
  


• 
  

  seizure (convulsions); or

  
  


• 
  

  a severe skin reaction.

  
  

Before receiving this vaccine, tell the doctor if you have:

• 
  

  a bleeding or blood clotting disorder such as hemophilia or easy bruising;

  
  


• 
  

  a history of seizures;

  
  


• 
  

  a neurologic disorder or disease affecting the brain (or if this was a reaction to a previous vaccine);

  
  


• 
  

  an allergy to latex rubber;

  
  


• 
  

  a weak immune system caused by disease, bone marrow transplant, or by using certain medicines or receiving cancer treatments; or

  
  


• 
  

  if you are taking a blood thinner such as warfarin (Coumadin).

  
  

You can still receive a vaccine if you have a cold or fever. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.

Vaccines may be harmful to an unborn baby and generally should not be given to a pregnant woman. However, not vaccinating the mother could be more harmful to the baby if the mother becomes infected with a disease that this vaccine could prevent. Your doctor will decide whether you should receive this vaccine, especially if you have a high risk of infection with diphtheria or tetanus. It is not known whether this vaccine passes into breast milk or if it could harm a nursing baby. Do not use receive the vaccine without telling your doctor if you are breast-feeding a baby. The adult version of this vaccine (Td) should not be given to anyone under the age of 7 years old. Another vaccine is available for use in younger children and infants.

How is this vaccine given?

This vaccine is given as an injection (shot) into a muscle. You will receive this injection in a doctor's office or other clinic setting.

The tetanus and diphtheria toxoids vaccine is given in a series of shots. The first shot is usually given to a person who is at least 7 years old. The booster shots are then given 4 to 8 weeks after the first shot, and 6 to 12 months after the second shot. After the initial series, a booster dose is given every 10 years.

A booster shot is also recommended in children who are 11 or 12 years old if more than 5 years have passed since the child's last tetanus and diphtheria vaccine.

If it has been longer than 5 years since your last booster, you may need an emergency booster shot if you have been exposed to tetanus through a skin wound.

Your individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by the health department of the state you live in.

Your doctor may recommend treating fever and pain with an aspirin-free pain reliever such as acetaminophen (Tylenol) or ibuprofen (Motrin, Advil, and others) when the shot is given and for the next 24 hours. Follow the label directions or your doctor's instructions about how much of this medicine to take.

It is especially important to prevent fever from occurring if you have a seizure disorder such as epilepsy.

What happens if I miss a dose?

Contact your doctor if you will miss a booster dose or if you get behind schedule. The next dose should be given as soon as possible. There is no need to start over.

Be sure you receive all recommended doses of this vaccine. If you do not receive the full series of vaccines, you may not be fully protected against the disease.

What happens if I overdose?

An overdose of this vaccine is unlikely to occur.

What should I avoid before or after receiving this vaccine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

This vaccine side effects

You should not receive a booster vaccine if you have had a life-threatening allergic reaction after the first shot. Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with tetanus or diphtheria is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• 
  

  extreme drowsiness, fainting;

  
  


• 
  

  severe headache or vomiting;

  
  


• 
  

  confusion, seizure (black-out or convulsions); or

  
  


• 
  

  high fever.

  
  

Less serious side effects include:

• 
  

  redness, pain, tenderness, swelling, or a hard lump where the shot was given;

  
  


• 
  

  mild fever;

  
  


• 
  

  joint pain, body aches;

  
  


• 
  

  mild drowsiness; or

  
  


• 
  

  mild vomiting.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

Tetanus and diphtheria toxoids vaccine Dosing Information

Usual Adult Dose for Diphtheria Prophylaxis:

2 doses of 0.5 mL IM 4 to 6 weeks apart followed by a third dose of 0.5 mL after 6 to 12 months later.

A booster dose is recommended every 10 years.

Tetanus prophylaxis in wound management:
Use of tetanus toxoid (DT or Td) and/or tetanus immune globulin (TIG) depends upon the number of prior tetanus toxoid (TT) doses and type of wound: A single 0.5 mL dose IM:
Clean, minor wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 10 years since last dose
If only three doses of fluid tetanus toxoid have been received, a fourth dose of toxoid, preferably an adsorbed toxoid, should be given.
All other wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap (tetanus/diphtheria/pertussis, accel) and TIG (tetanus immune globulin)
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 5 years since last dose

Use of combined antigen immunization (DT, Td, or DTaP - diphtheria/tetanus/pertussis, accel) is preferred. Use tetanus and diphtheria toxoids formulation based upon age; use pediatric preparations (DT or DTaP) if the patient is less than 7 years old and Td if 7 years or older. Tdap is preferred in adolescents 10 years or older and adults who have never received Tdap. Td is preferred to TT in adolescents 10 years or older and adults who received Tdap previously or when Tdap is not available. If TT and TIG are both used, tetanus toxoid (adsorbed) rather than tetanus toxoid (fluid) should be used.

Usual Adult Dose for Tetanus Prophylaxis:

2 doses of 0.5 mL IM 4 to 6 weeks apart followed by a third dose of 0.5 mL after 6 to 12 months later.

A booster dose is recommended every 10 years.

Tetanus prophylaxis in wound management:
Use of tetanus toxoid (DT or Td) and/or tetanus immune globulin (TIG) depends upon the number of prior tetanus toxoid (TT) doses and type of wound: A single 0.5 mL dose IM:
Clean, minor wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 10 years since last dose
If only three doses of fluid tetanus toxoid have been received, a fourth dose of toxoid, preferably an adsorbed toxoid, should be given.
All other wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap (tetanus/diphtheria/pertussis, accel) and TIG (tetanus immune globulin)
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 5 years since last dose

Use of combined antigen immunization (DT, Td, or DTaP - diphtheria/tetanus/pertussis, accel) is preferred. Use tetanus and diphtheria toxoids formulation based upon age; use pediatric preparations (DT or DTaP) if the patient is less than 7 years old and Td if 7 years or older. Tdap is preferred in adolescents 10 years or older and adults who have never received Tdap. Td is preferred to TT in adolescents 10 years or older and adults who received Tdap previously or when Tdap is not available. If TT and TIG are both used, tetanus toxoid (adsorbed) rather than tetanus toxoid (fluid) should be used.

Usual Pediatric Dose for Diphtheria Prophylaxis:

7 years and older:
Primary Immunization:
2 doses of 0.5 mL IM 4 to 6 weeks apart followed by a third dose of 0.5 mL after 6 to 12 months later.
Booster Immunization:
Children 11 to 12 years: A single dose when at least 5 years have elapsed since last dose of toxoid containing vaccine.

Tetanus prophylaxis in wound management:
Use of tetanus toxoid (DT or Td) and/or tetanus immune globulin (TIG) depends upon the number of prior tetanus toxoid (TT) doses and type of wound: A single 0.5 mL dose IM:
Clean, minor wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 10 years since last dose
If only three doses of fluid tetanus toxoid have been received, a fourth dose of toxoid, preferably an adsorbed toxoid, should be given.
All other wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap (tetanus/diphtheria/pertussis, accel) and TIG (tetanus immune globulin)
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 5 years since last dose.

Use of combined antigen immunization (DT, Td, or DTaP - diphtheria/tetanus/pertussis, accel) is preferred. Use tetanus and diphtheria toxoids formulation based upon age; use pediatric preparations (DT or DTaP) if the patient is less than 7 years old and Td if 7 years or older. Tdap is preferred in adolescents 10 years or older and adults who have never received Tdap. Td is preferred to TT in adolescents 10 years or older and adults who received Tdap previously or when Tdap is not available. If TT and TIG are both used, tetanus toxoid (adsorbed) rather than tetanus toxoid (fluid) should be used.

Usual Pediatric Dose for Tetanus Prophylaxis:

7 years and older:
Primary Immunization:
2 doses of 0.5 mL IM 4 to 6 weeks apart followed by a third dose of 0.5 mL after 6 to 12 months later.
Booster Immunization:
Children 11 to 12 years: A single dose when at least 5 years have elapsed since last dose of toxoid containing vaccine.

Tetanus prophylaxis in wound management:
Use of tetanus toxoid (DT or Td) and/or tetanus immune globulin (TIG) depends upon the number of prior tetanus toxoid (TT) doses and type of wound: A single 0.5 mL dose IM:
Clean, minor wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 10 years since last dose
If only three doses of fluid tetanus toxoid have been received, a fourth dose of toxoid, preferably an adsorbed toxoid, should be given.
All other wounds:
Prior number of tetanus toxoid doses is unknown or less than 3: DT or Td or Tdap (tetanus/diphtheria/pertussis, accel) and TIG (tetanus immune globulin)
Prior number of tetanus toxoid doses is 3 or more: Td only if more than 5 years since last dose.

Use of combined antigen immunization (DT, Td, or DTaP - diphtheria/tetanus/pertussis, accel) is preferred. Use tetanus and diphtheria toxoids formulation based upon age; use pediatric preparations (DT or DTaP) if the patient is less than 7 years old and Td if 7 years or older. Tdap is preferred in adolescents 10 years or older and adults who have never received Tdap. Td is preferred to TT in adolescents 10 years or older and adults who received Tdap previously or when Tdap is not available. If TT and TIG are both used, tetanus toxoid (adsorbed) rather than tetanus toxoid (fluid) should be used.

What other drugs will affect tetanus and diphtheria toxoids vaccine?

Before receiving this vaccine, tell your doctor about all other vaccines you have recently received.

Also tell the doctor if you have received drugs or treatments in the past 2 weeks that can weaken the immune system, including:

• 
  

  an oral, nasal, inhaled, or injectable steroid medicine;

  
  


• 
  

  medications to treat psoriasis, rheumatoid arthritis, or other autoimmune disorders, such as azathioprine (Imuran), efalizumab (Raptiva), etanercept (Enbrel), leflunomide (Arava), and others; or

  
  


• 
  

  medicines to treat or prevent organ transplant rejection, such as basiliximab (Simulect), cyclosporine (Sandimmune, Neoral, Gengraf), muromonab-CD3 (Orthoclone), mycophenolate mofetil (CellCept), sirolimus (Rapamune), or tacrolimus (Prograf).

  
  

This list is not complete and there may be other drugs that can affect this vaccine. Tell your doctor about all the prescription and over-the-counter medications you are using. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More tetanus and diphtheria toxoids vaccine resources

• Tetanus and diphtheria toxoids vaccine Use in Pregnancy & Breastfeeding
• Tetanus and diphtheria toxoids vaccine Drug Interactions
• Tetanus and diphtheria toxoids vaccine Support Group
• 0 Reviews for Tetanus and diphtheria toxoids vaccine - Add your own review/rating

Compare tetanus and diphtheria toxoids vaccine with other medications

• Diphtheria Prophylaxis
• Tetanus Prophylaxis

Where can I get more information?

• Your doctor or pharmacist may have information about this vaccine written for health professionals that you may read. You may also find additional information from your local health department or the Centers for Disease Control and Prevention.

Solage

Pronunciation: ME-kwi-nole/TREH-tih-noyn
Generic Name: Mequinol/Tretinoin
Brand Name: Solage

Solage is used for:

Treating solar lentigines (darkened lesions on skin that has been exposed to sunlight over a long period of time). Solage is used with a total skin care and sunlight avoidance program. It may also be used for other conditions as determined by your doctor.

Solage is a combination depigmentation agent and retinoid. Exactly how it works is unknown.

Do NOT use Solage if:

• you are allergic to any ingredient in Solage


• you are taking a fluoroquinolone (eg, levofloxacin), a phenothiazine (eg, chlorpromazine), a sulfonamide (eg, glipizide, sulfamethoxazole), a tetracycline (eg, doxycycline), a thiazide diuretic (eg, hydrochlorothiazide), or other medicines that may increase your skin's sensitivity to the sun. Ask your doctor or pharmacist if you have questions about whether any of your medicines increase your skin's sun sensitivity.


• you are pregnant or may become pregnant

Contact your doctor or health care provider right away if any of these apply to you.

Before using Solage:

Some medical conditions may interact with Solage. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have eczema, irritated or inflamed skin, an increased number of white blood cells, vitiligo (loss of skin pigmentation), or sunburn


• if you are unusually sensitive to sunlight or must be outside for prolonged periods of time

Some MEDICINES MAY INTERACT with Solage. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Fluoroquinolones (eg, levofloxacin), phenothiazines (eg, chlorpromazine), sulfonamides (eg, glipizide, sulfamethoxazole), tetracyclines (eg, doxycycline), or thiazide diuretics (eg, hydrochlorothiazide) because the risk of sunburn may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Solage may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Solage:

Use Solage as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Solage. Talk to your pharmacist if you have questions about this information.


• Solage is for external use only.


• Use Solage twice daily, at least 8 hours apart, unless directed otherwise by your doctor.


• Remove all cosmetics with a mild soap before applying Solage. Gently dry the area. Wait 20 to 30 minutes to make sure that skin is completely dry.


• Use the applicator tip to apply Solage to the affected area. Use only enough to make the lesion appear moist. Avoid getting Solage on the surrounding, normally colored skin.


• Do not shower or bathe the treated areas for at least 6 hours after you apply Solage.


• Wait 30 minutes after applying Solage before you apply cosmetics.


• If you miss a dose of Solage, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Solage.

Important safety information:

• Avoid getting Solage in your eyes, on the inside or angles of your nose, or in your mouth. If you get Solage in your eyes, rinse thoroughly with water.


• Solage may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Solage. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Talk with your doctor before you use any other medicines or products on your skin. While you are using Solage, you may use cosmetics.


• Do not apply Solage to skin that is sunburned. Wait until the burn is fully healed before using Solage.


• Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Safety and effectiveness of Solage have not been established in patients with moderately dark to dark skin.


• Avoid using other topical medication, cosmetics, or other products that have a strong drying effect. If you have dry skin from using these products, allow your skin to "rest" before using Solage.


• If the lesion you have been treating becomes the same color as your normal skin, contact your doctor.


• Do not use Solage on skin with eczema, or for any condition other than that for which it was prescribed.


• Weather extremes, such as windy or cold weather, may irritate your skin more while you are using Solage.


• Solage may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.


• Solage should only be used in addition to a comprehensive skin care and sunlight avoidance program prepared by your doctor.


• Solage is flammable. Do not store or use near an open flame or while smoking.


• If you are able to become pregnant, use effective birth control while you are using Solage.


• Solage should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not use Solage if you are pregnant. If you think you may be pregnant, contact your doctor immediately. It is not known if Solage is found in breast milk. If you are or will be breast-feeding while you use Solage, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Solage:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Burning, dry skin, itching, peeling, redness, stinging, tingling, or warmth at application site; unusual sensitivity to wind and cold.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering, crusting, swelling, or excessive redness of the skin; changes in skin color; lightening of the skin surrounding the treatment area.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Solage side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include clumsiness; dizziness; excessive redness, peeling, and discomfort; flushing; headache; stomach pain.

Proper storage of Solage:

Store Solage at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat and light. Do not store in the bathroom. Keep Solage out of the reach of children and away from pets.

General information:

• If you have any questions about Solage, please talk with your doctor, pharmacist, or other health care provider.


• Solage is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Solage. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Solage resources

• Solage Side Effects (in more detail)
• Solage Use in Pregnancy & Breastfeeding
• Solage Drug Interactions
• Solage Support Group
• 0 Reviews for Solage - Add your own review/rating

• Solage Prescribing Information (FDA)


• Solage Concise Consumer Information (Cerner Multum)


• Solage Topical Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Solage with other medications

• Dermatological Disorders

Tylenol

Pronunciation: a-seet-a-MIN-oh-fen
Generic Name: Acetaminophen
Brand Name: Examples include Tylenol and Tylophen

Tylenol is used for:

Treating minor aches and pains due to headache, muscle aches, backache, arthritis, the common cold, flu, toothache, menstrual cramps, and immunizations, and for temporarily reducing fever.

Tylenol is an analgesic and antipyretic (lowers fever). It works by lowering a chemical in the brain that stimulates pain nerves and the heat-regulating center in the brain.

Do NOT use Tylenol if:

• you are allergic to any ingredient in Tylenol

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tylenol:

Some medical conditions may interact with Tylenol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of alcohol abuse or you drink more than 3 alcohol-containing drinks every day


• if you have liver or kidney problems, hepatitis, or phenylketonuria (PKU)

Some MEDICINES MAY INTERACT with Tylenol. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin) because the risk of their side effects, including bleeding, may be increased by Tylenol


• Isoniazid because the risk of liver problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tylenol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tylenol:

Use Tylenol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Tylenol by mouth with or without food.


• Replace original bottle cap to maintain child resistance.


• If you miss a dose of Tylenol and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tylenol.

Important safety information:

• Tylenol has acetaminophen in it. Before you start any new medicine, check the label to see if it has acetaminophen in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Tylenol may harm your liver. Your risk may be greater if you drink alcohol while you are using Tylenol. Talk to your doctor before you take Tylenol or other fever reducers if you drink more than 3 drinks with alcohol per day.


• Severe or persistent sore throat or sore throat accompanied by high fever, headache, nausea, and vomiting may be serious. Consult a doctor promptly. Do not use for more than 2 days or give to children younger than 3 years old unless directed by a doctor.


• Tylenol may cause the results of some in-home test kits for blood cholesterol to be wrong. Check with your doctor or pharmacist if you are taking Tylenol and need to check your blood cholesterol at home.


• For pain and fever in ADULTS: Stop use of Tylenol and ask your doctor if pain gets worse or lasts more than 10 days, fever gets worse or lasts more than 3 days, or new symptoms occur or redness or swelling is present.


• For pain and fever in CHILDREN: Stop use and ask a doctor if fever gets worse or lasts more than 3 days, pain gets worse or lasts more than 5 days, or redness or swelling is present or any new symptoms appear.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tylenol while you are pregnant. Tylenol is found in breast milk. If you are or will be breast-feeding while you use Tylenol, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Tylenol:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine or pale stools; unusual fatigue; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tylenol side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dark urine; excessive sweating; extreme fatigue; nausea and vomiting; stomach pain.

Proper storage of Tylenol:

Store Tylenol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tylenol out of the reach of children and away from pets.

General information:

• If you have any questions about Tylenol, please talk with your doctor, pharmacist, or other health care provider.


• Tylenol is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tylenol. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tylenol resources

• Tylenol Side Effects (in more detail)
• Tylenol Use in Pregnancy & Breastfeeding
• Drug Images
• Tylenol Drug Interactions
• Tylenol Support Group
• 8 Reviews for Tylenol - Add your own review/rating

• Tylenol Consumer Overview


• Tylenol Advanced Consumer (Micromedex) - Includes Dosage Information


• acetaminophen Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• Acetaminophen Monograph (AHFS DI)


• Acetazolamide Monograph (AHFS DI)


• Apraclonidine Hydrochloride Monograph (AHFS DI)


• Ofirmev Consumer Overview


• Ofirmev Prescribing Information (FDA)


• Paracetamol Consumer Overview

Compare Tylenol with other medications

• Fever
• Muscle Pain
• Pain
• Sciatica

Theraflu Cold & Sore Throat (pseudoephedrine)

Generic Name: acetaminophen, chlorpheniramine, and pseudoephedrine (a seet a MIN oh fen, klor fen IR a meen, soo doe e FED rin)

Brand Names: Alka-Seltzer Plus Cold Liquigel, Allerest Headache Strength, Allerest Sinus, Cold Medicine Plus, Comtrex Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Comtrex Allergy Sinus Night and Day, Kolephrin, Sinarest, Sinutab Ex-Strength, Theraflu Cold & Sore Throat (pseudoephedrine), Theraflu Flu & Sore Throat (pseudoephedrine), Theraflu Maximum Strength

What is Theraflu Cold & Sore Throat (pseudoephedrine) (acetaminophen, chlorpheniramine, and pseudoephedrine)?

Acetaminophen is a pain reliever and fever reducer.

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of acetaminophen, chlorpheniramine, and pseudoephedrine is used to treat headache, fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Acetaminophen, chlorpheniramine, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Theraflu Cold & Sore Throat (pseudoephedrine) (acetaminophen, chlorpheniramine, and pseudoephedrine)?

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen and can increase certain side effects of chlorpheniramine. Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose.

What should I discuss with my healthcare provider before taking Theraflu Cold & Sore Throat (pseudoephedrine) (acetaminophen, chlorpheniramine, and pseudoephedrine)?

You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

• 
  

  liver disease, cirrhosis, or a history of alcoholism;

  
  


• 
  

  a blockage in your digestive tract (stomach or intestines);

  
  


• 
  

  diabetes;

  
  


• 
  

  kidney disease;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis;

  
  


• 
  

  enlarged prostate or urination problems;

  
  


• 
  

  low blood pressure;

  
  


• 
  

  pheochromocytoma (an adrenal gland tumor); or

  
  


• 
  

  if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

  
  

It is not known whether acetaminophen, chlorpheniramine, and pseudoephedrine will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant. This medication may pass into breast milk and may harm a nursing baby. Antihistamines and decongestants may also slow breast milk production. Do not use this medicine without your doctor's advice if you are breast-feeding a baby.

How should I take Theraflu Cold & Sore Throat (pseudoephedrine) (acetaminophen, chlorpheniramine, and pseudoephedrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Dissolve one packet of the powder in at least 4 ounces of water. Stir this mixture and drink all of it right away.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not take for longer than 7 days in a row. Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days. Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.

What happens if I miss a dose?

Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1 800 222 1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking Theraflu Cold & Sore Throat (pseudoephedrine) (acetaminophen, chlorpheniramine, and pseudoephedrine)?

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen, and can increase certain side effects of chlorpheniramine. This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Theraflu Cold & Sore Throat (pseudoephedrine) (acetaminophen, chlorpheniramine, and pseudoephedrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  chest pain, rapid pulse, fast or uneven heart rate;

  
  


• 
  

  confusion, hallucinations, severe nervousness;

  
  


• 
  

  tremor, seizure (convulsions);

  
  


• 
  

  easy bruising or bleeding, unusual weakness;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes); or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  dizziness, drowsiness;

  
  


• 
  

  mild headache;

  
  


• 
  

  dry mouth, nose, or throat;

  
  


• 
  

  constipation;

  
  


• 
  

  blurred vision;

  
  


• 
  

  feeling nervous; or

  
  


• 
  

  sleep problems (insomnia);

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Theraflu Cold & Sore Throat (pseudoephedrine) (acetaminophen, chlorpheniramine, and pseudoephedrine)?

Ask a doctor or pharmacist before using this medicine if you regularly use other medicines that make you sleepy (such as narcotic pain medication, sedatives, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by chlorpheniramine.

Tell your doctor about all other medicines you use, especially:

• 
  

  leflunomide (Arava);

  
  


• 
  

  topiramate (Topamax);

  
  


• 
  

  zonisamide (Zonegran);

  
  


• 
  

  an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;

  
  


• 
  

  an antidepressant;

  
  


• 
  

  birth control pills or hormone replacement therapy;

  
  


• 
  

  bladder or urinary medications;

  
  


• 
  

  blood pressure medication;

  
  


• 
  

  a bronchodilator;

  
  


• 
  

  cancer medicine;

  
  


• 
  

  cholesterol-lowering medications such as Lipitor, Niaspan, Zocor, Vytorin, and others;

  
  


• 
  

  gout or arthritis medications (including gold injections);

  
  


• 
  

  HIV/AIDS medication;

  
  


• 
  

  medication for nausea and vomiting, stomach ulcers, or irritable bowel syndrome;

  
  


• 
  

  medicines to treat psychiatric disorders;

  
  


• 
  

  an NSAID such as Advil, Aleve, Arthrotec, Cataflam, Celebrex, Indocin, Motrin, Naprosyn, Treximet, Voltaren, others; or

  
  


• 
  

  seizure medication.

  
  

This list is not complete and other drugs may interact with acetaminophen, chlorpheniramine, and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Theraflu Cold & Sore Throat (pseudoephedrine) resources

• Theraflu Cold & Sore Throat (pseudoephedrine) Side Effects (in more detail)
• Theraflu Cold & Sore Throat (pseudoephedrine) Use in Pregnancy & Breastfeeding
• Theraflu Cold & Sore Throat (pseudoephedrine) Drug Interactions
• Theraflu Cold & Sore Throat (pseudoephedrine) Support Group
• 0 Reviews for Theraflu Cold & Sore Throat (pseudoephedrine) - Add your own review/rating

• Children's Tylenol Cold Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Theraflu Cold & Sore Throat (pseudoephedrine) with other medications

• Cold Symptoms
• Hay Fever

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen, chlorpheniramine, and pseudoephedrine.

See also: Theraflu Cold & Sore Throat (pseudoephedrine) side effects (in more detail)

Sudafed PE Severe Cold

Generic Name: acetaminophen, diphenhydramine, and phenylephrine (a SEET a MIN oh fen, DYE fen HYE dra meen, and FEN il EFF rin)

Brand Names: Benadryl Allergy & Cold, Benadryl Allergy & Sinus Headache, Robitussin Nighttime Multi-Symptom Cold, Sudafed PE Severe Cold, Theraflu Severe Cold & Cough Nighttime, Theraflu Warming Flu & Sore Throat, Theraflu Warming Severe Cold Nighttime, Theraflu Warming Sinus & Cold

What is Sudafed PE Severe Cold (acetaminophen, diphenhydramine, and phenylephrine)?

Acetaminophen is a pain reliever and fever reducer.

Diphenhydramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of acetaminophen, diphenhydramine, and phenylephrine is used to treat headache, fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Acetaminophen, diphenhydramine, and phenylephrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Sudafed PE Severe Cold (acetaminophen, diphenhydramine, and phenylephrine)?

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen and can increase certain side effects of diphenhydramine. Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose.

What should I discuss with my healthcare provider before taking Sudafed PE Severe Cold (acetaminophen, diphenhydramine, and phenylephrine)?

You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

• 
  

  liver disease, cirrhosis, or a history of alcoholism;

  
  


• 
  

  a blockage in your digestive tract (stomach or intestines);

  
  


• 
  

  diabetes;

  
  


• 
  

  kidney disease;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis;

  
  


• 
  

  enlarged prostate or urination problems;

  
  


• 
  

  low blood pressure;

  
  


• 
  

  pheochromocytoma (an adrenal gland tumor); or

  
  


• 
  

  if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

  
  

It is not known whether acetaminophen, diphenhydramine, and phenylephrine will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant. This medication may pass into breast milk and may harm a nursing baby. Antihistamines and decongestants may also slow breast milk production. Do not use this medicine without your doctor's advice if you are breast-feeding a baby.

How should I take Sudafed PE Severe Cold (acetaminophen, diphenhydramine, and phenylephrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Dissolve one packet of the powder in at least 4 ounces of water. Stir this mixture and drink all of it right away.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not take for longer than 7 days in a row. Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days. Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.

What happens if I miss a dose?

Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1 800 222 1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking Sudafed PE Severe Cold (acetaminophen, diphenhydramine, and phenylephrine)?

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen, and can increase certain side effects of diphenhydramine. This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Sudafed PE Severe Cold (acetaminophen, diphenhydramine, and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  chest pain, rapid pulse, fast or uneven heart rate;

  
  


• 
  

  confusion, hallucinations, severe nervousness;

  
  


• 
  

  tremor, seizure (convulsions);

  
  


• 
  

  easy bruising or bleeding, unusual weakness;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes); or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  dizziness, drowsiness, mild headache;

  
  


• 
  

  dry mouth, nose, or throat;

  
  


• 
  

  constipation;

  
  


• 
  

  blurred vision;

  
  


• 
  

  feeling nervous; or

  
  


• 
  

  sleep problems (insomnia);

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Sudafed PE Severe Cold (acetaminophen, diphenhydramine, and phenylephrine)?

Ask a doctor or pharmacist before using this medicine if you regularly use other medicines that make you sleepy (such as narcotic pain medication, sedatives, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by diphenhydramine.

Tell your doctor about all other medicines you use, especially:

• 
  

  leflunomide (Arava);

  
  


• 
  

  topiramate (Topamax);

  
  


• 
  

  zonisamide (Zonegran);

  
  


• 
  

  diphenhydramine (Benadryl) applied to the skin;

  
  


• 
  

  an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;

  
  


• 
  

  an antidepressant;

  
  


• 
  

  birth control pills or hormone replacement therapy;

  
  


• 
  

  bladder or urinary medications;

  
  


• 
  

  blood pressure medication;

  
  


• 
  

  a bronchodilator;

  
  


• 
  

  cancer medicine;

  
  


• 
  

  cholesterol-lowering medications such as Lipitor, Niaspan, Zocor, Vytorin, and others;

  
  


• 
  

  gout or arthritis medications (including gold injections);

  
  


• 
  

  HIV/AIDS medication;

  
  


• 
  

  medication for nausea and vomiting, stomach ulcers, or irritable bowel syndrome;

  
  


• 
  

  medicines to treat psychiatric disorders;

  
  


• 
  

  an NSAID such as Advil, Aleve, Arthrotec, Cataflam, Celebrex, Indocin, Motrin, Naprosyn, Treximet, Voltaren, others; or

  
  


• 
  

  seizure medication.

  
  

This list is not complete and other drugs may interact with acetaminophen, diphenhydramine, and phenylephrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Sudafed PE Severe Cold resources

• Sudafed PE Severe Cold Side Effects (in more detail)
• Sudafed PE Severe Cold Use in Pregnancy & Breastfeeding
• Sudafed PE Severe Cold Drug Interactions
• Sudafed PE Severe Cold Support Group
• 2 Reviews for Sudafed PE Severe Cold - Add your own review/rating

Compare Sudafed PE Severe Cold with other medications

• Cold Symptoms

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen, diphenhydramine, and phenylephrine.

See also: Sudafed PE Severe Cold side effects (in more detail)

Trioxsalen

trye-OX-sa-len

Available Dosage Forms:

• Tablet

Therapeutic Class: Antipsoriatic

Chemical Class: Psoralen

Uses For trioxsalen

Trioxsalen belongs to the group of medicines called psoralens. It is used along with ultraviolet light (found in sunlight and some special lamps) in a treatment called psoralen plus ultraviolet light A (PUVA) to treat vitiligo, a disease in which skin color is lost. Trioxsalen may also be used for other conditions as determined by your doctor.

Trioxsalen was available only with your doctor's prescription.

Trioxsalen was discontinued by the manufacturer in December 2002.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, trioxsalen is used in certain patients with the following medical condition:

• Psoriasis

Before Using trioxsalen

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For trioxsalen, the following should be considered:

Trioxsalen is a very strong medicine that increases the skin's sensitivity to sunlight. In addition to causing serious sunburns if not properly used, it has been reported to increase the chance of skin cancer and cataracts. Also, like too much sunlight, PUVA can cause premature aging of the skin. Therefore, trioxsalen should be used only as directed and it should not be used simply for suntanning. Before using trioxsalen, be sure that you have discussed its use with your doctor.

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to trioxsalen or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of trioxsalen in children with use in other age groups, trioxsalen is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of trioxsalen in the elderly with use in other age groups.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of trioxsalen. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergy to sunlight (family history of) or


• Lupus erythematosus or


• Porphyria or


• Other conditions that make you more sensitive to light—trioxsalen will make the condition worse.

• Eye problems, such as cataracts or loss of the lens of the eyes—Use of trioxsalen may make your cataracts or other eye problems worse; having no lens in your eye may increase the side effects of trioxsalen.

• Heart or blood vessel disease (severe)—The heat from the light treatment may make the condition worse.

• Infection or


• Stomach problems—Use of trioxsalen may make the condition worse.

• Melanoma or other skin cancer (history of) or


• Recent treatment with x-rays or cancer medicines or plans to have x-rays in the near future—May increase your chance of skin cancer.

Proper Use of trioxsalen

trioxsalen may take several weeks or months to help your condition. Do not increase the amount of trioxsalen you are taking or spend extra time in the sunlight or under an ultraviolet lamp. This will not make the medicine act any more quickly and may result in a serious burn.

If trioxsalen upsets your stomach, it may be taken with meals or milk.

Dosing

The dose of trioxsalen will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of trioxsalen. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For vitiligo:
    
    • Adults and children 12 years of age and over—20 to 40 milligrams (mg) taken two to four hours before ultraviolet light A (UVA) exposure. This treatment (trioxsalen and UVA) is given two or three times a week with the treatments spaced at least forty-eight hours apart.
    
    
    • Children up to 12 years of age—Dose must be determined by your doctor.
    
    
  
  
  • For increasing tolerance to sunlight or increasing color of the skin:
    
    • Adults and children 12 years of age and over—20 to 40 mg taken two hours before ultraviolet light A (UVA) exposure. This treatment (trioxsalen and UVA) is given two or three times a week with the treatments spaced at least forty-eight hours apart.
    
    
    • Children up to 12 years of age—Dose must be determined by your doctor.
    
    
  
  

Missed Dose

Call your doctor or pharmacist for instructions.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using trioxsalen

Your doctor should check your progress at regular visits to make sure trioxsalen is working and that it does not cause unwanted effects. Eye examinations should be included.

trioxsalen increases the sensitivity of your skin and lips to sunlight. Therefore, exposure to the sun, even through window glass or on a cloudy day, could cause a serious burn. If you must go out during the daylight hours:

• Before each treatment, cover your skin for at least 24 hours by wearing protective clothing, such as long-sleeved shirts, full-length slacks, wide-brimmed hat, and gloves. In addition, protect your lips with a special sun block lipstick that has a skin protection factor of at least 15. Check with your doctor before using sun block products on other parts of your body before a treatment, since sun block products should not be used on the areas of your skin that are to be treated.


• After each treatment, cover your skin for at least 8 hours by wearing protective clothing. In addition, use a sun block product that has a skin protection factor of at least 15 on your lips and on those areas of your body that cannot be covered.

If you have any questions about this, check with your health care professional.

Your skin may continue to be sensitive to sunlight for some time after treatment with trioxsalen. Use extra caution for at least 48 hours following each treatment if you plan to spend any time in the sun. Do not sunbathe during this time.

For 24 hours after you take each dose of trioxsalen, your eyes should be protected during daylight hours with special wraparound sunglasses that totally block or absorb ultraviolet light (ordinary sunglasses are not adequate). This is to prevent cataracts. Your doctor will tell you what kind of sunglasses to use. These glasses should be worn even in indirect light, such as light coming through window glass or on a cloudy day.

Eating certain foods while you are taking trioxsalen may increase your skin's sensitivity to sunlight. To help prevent this, avoid eating limes, figs, parsley, parsnips, mustard, carrots, and celery while you are being treated with trioxsalen.

trioxsalen may cause your skin to become dry or itchy. However, check with your doctor before applying anything to your skin to treat this problem.

trioxsalen Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Blistering and peeling of skin


• reddened, sore skin


• swelling, especially of feet or lower legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Itching of skin


• nausea

Less common

• Dizziness


• headache


• mental depression


• nervousness


• trouble in sleeping

There is an increased risk of developing skin cancer after use of trioxsalen. You should check your body regularly and show your doctor any skin sores that do not heal, new skin growths, and skin growths that have changed in the way they look or feel.

Premature aging of the skin may occur as a result of prolonged trioxsalen therapy. This effect is permanent and is similar to what happens when a person sunbathes for long periods of time.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More trioxsalen resources

• Trioxsalen Drug Interactions
• Trioxsalen Support Group
• 0 Reviews · Be the first to review/rate this drug

Tamoxifen Solution

Generic Name: Tamoxifen (ta-MOX-i-fen)
Brand Name: Soltamox

Women taking Tamoxifen Solution to decrease the risk of developing breast cancer have developed cancer of the uterus, stroke, and blood clots in the lung. Some of these events have been fatal. Contact your doctor right away if you develop any of the following: unusual vaginal bleeding or discharge; abnormal menstrual period; groin pressure or pain; chest pain; shortness of breath; coughing up blood; confusion; one-sided weakness; vision or speech problems.

Women at high risk of breast cancer or with ductal carcinoma in situ (DCIS) should discuss the use of Tamoxifen Solution with their doctor. Decide if the possible benefits (reducing the risk of breast cancer) outweigh the risk of these events. The benefits of Tamoxifen Solution outweigh the risks in women who already have breast cancer.

Tamoxifen Solution is used for:

Treating breast cancer that has spread to other sites in the body.It is also used along with other medicines to treat other types of breast cancer. It is used in women who are at high risk for breast cancer and in women with DCIS (after surgery and radiation) to decrease the risk of developing breast cancer. It may also be used for other conditions as determined by your doctor.

Tamoxifen Solution is an antiestrogen. It works by blocking the effect of estrogen on certain tumors. This may prevent the growth of tumors that are activated by estrogen.

Do NOT use Tamoxifen Solution if:

• you are allergic to any ingredient in Tamoxifen Solution


• you are using Tamoxifen Solution to reduce your risk of breast cancer and you have a history of blood clots in the lung or leg


• you are using Tamoxifen Solution to reduce your risk of breast cancer and you also take certain anticoagulants (eg, warfarin)


• you are taking anastrozole

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tamoxifen Solution:

Some medical conditions may interact with Tamoxifen Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of blood clots in the legs or lungs


• if you have high levels of calcium in your blood, a weakened immune system, or low levels of white blood cells or platelets in your blood


• if you have high cholesterol or lipid levels


• if you have cataracts or other vision problems


• if you are using cytotoxic cancer medicines


• if you are confined to a bed or chair

Some MEDICINES MAY INTERACT with Tamoxifen Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin) because the risk of bleeding may be increased


• Cytotoxic cancer medicines (eg, cisplatin) because the risk of developing blood clots may be increased


• Rifampin because it may decrease Tamoxifen Solution's effectiveness


• Fluorouracil or mitomycin C because they may increase the risk of Tamoxifen Solution's side effects


• Aromatase inhibitors (eg, anastrozole, letrozole) because their effectiveness may be decreased by Tamoxifen Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tamoxifen Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tamoxifen Solution:

Use Tamoxifen Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Tamoxifen Solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Tamoxifen Solution refilled.


• Tamoxifen Solution may be taken by mouth with or without food.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Continue to take Tamoxifen Solution even if you feel well. Do not miss any doses. Taking Tamoxifen Solution at the same time each day will help you to remember to take it.


• If you miss a dose of Tamoxifen Solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tamoxifen Solution.

Important safety information:

• Tamoxifen Solution may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Tamoxifen Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Tamoxifen Solution may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.


• Tamoxifen Solution may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• New tumors have occurred in body sites other than the uterus in patients taking Tamoxifen Solution. It is unknown if Tamoxifen Solution may be the cause. Discuss any questions or concerns with your doctor.


• Women who take Tamoxifen Solution to reduce the risk of breast cancer should have a breast exam, mammogram, and gynecological exam before starting and during treatment with Tamoxifen Solution.


• Women who may become pregnant should begin taking Tamoxifen Solution during a menstrual period. Women who have irregular menstrual periods should have a pregnancy test immediately before starting Tamoxifen Solution. Talk to your doctor if you have any questions about how to begin taking Tamoxifen Solution.


• Women who may become pregnant must use effective nonhormonal birth control (eg, condoms, diaphragm) during sexual intercourse while they are taking Tamoxifen Solution and for 2 months after they stop taking it. Do not use hormonal birth control (eg, birth control pills); it may not work as well while you are taking Tamoxifen Solution. Discuss any questions about effective nonhormonal birth control with your doctor.


• Tamoxifen Solution will not prevent you from becoming pregnant.


• Lab tests, including breast exams, mammograms, gynecologic exams,complete blood counts, and liver function tests, may be performed while you use Tamoxifen Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Tamoxifen Solution should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Tamoxifen Solution may cause harm to the fetus. Do not become pregnant while you are using it and for 2 months after you stop using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tamoxifen Solution while you are pregnant. It is not known if Tamoxifen Solution is found in breast milk. Do not breast-feed while taking Tamoxifen Solution.

Possible side effects of Tamoxifen Solution:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bone pain; constipation; coughing; hot flashes; muscle pain; nausea; tiredness; vaginal discharge; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unexplained hoarseness); abnormal menstrual periods; abnormal vaginal bleeding or bloody discharge; chest pain; coughing up blood; dark urine; decreased sexual desire or ability; depression; fever, chills, or persistent sore throat; groin or pelvic pain or pressure; loss of appetite; loss of balance or coordination; missed menstrual period; new or increased breast tumor or pain; new or unusual lumps; one-sided weakness; pain or swelling in one or both legs; red, swollen, blistered, or peeling skin; severe or persistent tiredness or weakness; shortness of breath; skin changes; stomach pain; sudden severe headache; swelling of the arms or the legs; unusual bleeding or bruising; vision or speech problems; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tamoxifen side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include exaggerated reflexes; seizures; severe or persistent dizziness; tremor; trouble breathing; trouble walking.

Proper storage of Tamoxifen Solution:

Store Tamoxifen Solution at room temperature, below 77 degrees F (25 degrees C), in the original container. Do NOT refrigerate or freeze. Store away from moisture, heat, and light. Do not store in the bathroom. Throw away any unused medicine 3 months after the bottle is opened. Keep Tamoxifen Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Tamoxifen Solution, please talk with your doctor, pharmacist, or other health care provider.


• Tamoxifen Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Tamoxifen Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tamoxifen resources

• Tamoxifen Side Effects (in more detail)
• Tamoxifen Dosage
• Tamoxifen Use in Pregnancy & Breastfeeding
• Drug Images
• Tamoxifen Drug Interactions
• Tamoxifen Support Group
• 7 Reviews for Tamoxifen - Add your own review/rating

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